IPD-1151T (Suplatast Tosilate) Inhibits Interleukin (IL)-13 Release but Not IL-4 Release From Basophils
نویسندگان
چکیده
منابع مشابه
Intravesical suplatast tosilate (IPD-1151T) inhibits experimental bladder inflammation.
PURPOSE Interstitial cystitis is a painful bladder disease characterized by urgency, frequency and variable inflammation but there is no curative therapy. Suplatast tosilate (IPD-1151T) is an immunoregulatory compound that decreases interstitial cystitis symptoms but to our knowledge its mechanism of action is unknown. We investigated the effect of intravesical IPD-1151T on mediator release fro...
متن کاملevaluation of the correlation and reproducibility between histamine, il-4, and il-13 release from human basophils.
human basophils play a key role in allergic diseases such as asthma and in a variety of immunological disorders. the generation of il-4 and il-13 can be induced from basophil by ige-mediated and non-ige-mediated mechanisms. time and stimulus- dependent differences in the regulation of these cytokines could have relevance to their biological effects. the aim o...
متن کاملIl-4 and IL-13, but not IL-10, protect human synoviocytes from apoptosis.
Interleukin-4, which has been contemplated for the treatment of rheumatoid arthritis and/or osteoarthritis because of its anticatabolic properties, has also been shown to modulate apoptosis. Because inadequate apoptosis is thought to contribute to synovial hyperplasia, we have investigated the ability of IL-4 and other Th2 cytokines to protect human synovial cells from apoptosis. Human synovioc...
متن کاملInterleukin-4 (IL-4) enhances and soluble interleukin-4 receptor (sIL-4R) inhibits histamine release from peripheral blood basophils and mast cells in vitro and in vivo
The aim of the study was to analyse the effect of interleukin-4 (IL-4) on allergen and anti-IgE mediated histamine release from basophils and human skin mast cells and to assess whether soluble recombinant interleukin-4 receptor (sIL4R) can inhibit these effects. Anti-IgE stimulated histamine release from peripheral blood basophils and mast cells of atopic donors was enhanced after preincubatio...
متن کاملMite antigen-induced IL-4 and IL-13 production by basophils derived from atopic asthma patients.
BACKGROUND There is increasing evidence for the role of basophils in the pathogenesis of atopic diseases such as bronchial asthma, atopic dermatitis and atopic rhinitis. Recently, it has been reported that basophils derived from healthy donors produce the immunoregulatory cytokines interleukin (IL)-4 and IL-13 after cross-linking of cell surface IgE. In addition to well-known inflammatory media...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1999
ISSN: 0021-5198
DOI: 10.1254/jjp.79.501